N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

Base Information

Chemical Name:N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide
CAS No.:165674-25-9
Molecular Formula:C₂₈H₂₈F₃NO₁₀
Molecular Weight:595.526
Hs Code.:

N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

Synonyms:N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

Suppliers and Price of N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

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Chemical Property of N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

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Technology Process of N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

There total 20 articles about N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165674-18-0
6-((2S,3R)-3-<(5S,4R)-5-<(1Z)-2-aza-2-(phenylmethoxy)vinyl>-2,2-dimethyl(1,3-dioxolan-4-yl)>-3-(methoxymethoxy)-2-(1,1,2,2-tetramethyl-1-silapropoxy)propanoyl)-2H-benzo-1,3-dioxolane-5-carbaldehyde

: 165674-25-9
N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: HF*pyridine / tetrahydrofuran; pyridine / 24 h / Ambient temperature

2: imidazole / pentane / 19 h / Ambient temperature

3: 205 mg / NaBH₄ / methanol / 2 h / Ambient temperature

4: DMAP / 1,2-dichloro-ethane / 14 h / Heating

5: 2,2-azobis<2-methylpropionitrile>, Bu₃SnH / toluene / 0.5 h / Heating

6: 51 mg / DMAP, pyridine / CH₂Cl₂ / 0.5 h

7: 60 mg / TBAF / tetrahydrofuran / 1 h / -5 °C

8: NMO, tetrapropylammonium perruthenate / 0.75 h / Ambient temperature

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; pyridine hydrogenfluoride; In tetrahydrofuran; pyridine; methanol; dichloromethane; 1,2-dichloro-ethane; toluene; pentane;
DOI:10.1021/jo9902042

Reference yield:

: 236388-00-4
<(4S,12S,12aS,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-(1,1,2,2-tetramethyl-1-silapropoxy)(4,12,11b,12a,3a,4a-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>(phenylmethoxy)amine

: 165674-25-9
N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 51 mg / DMAP, pyridine / CH₂Cl₂ / 0.5 h

2: 60 mg / TBAF / tetrahydrofuran / 1 h / -5 °C

3: NMO, tetrapropylammonium perruthenate / 0.75 h / Ambient temperature

With pyridine; dmap; N-methyl-2-indolinone; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo9902042

Reference yield:

: (4S,5S)-5-{(S)-[(R)-5-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isochromen-7-yl]-methoxymethoxy-methyl}-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde O-benzyl-oxime

: 165674-25-9
N-<(12S,12aS,4R,11bR,3aR,4aR)-4-(methoxymethoxy)-2,2-dimethyl-6-oxo(4,12,11b,12a,3a,4a,-hexahydro-9H-1,3-dioxoleno<4,5-7',6'>isochromano-<4',3'-5,4>benzo<1,2-d>1,3-dioxolan-12-yl)>-2,2,2-trifluoro-N-(phenylmethoxy)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: DMAP / 1,2-dichloro-ethane / 14 h / Heating

2: 2,2-azobis<2-methylpropionitrile>, Bu₃SnH / toluene / 0.5 h / Heating

3: 51 mg / DMAP, pyridine / CH₂Cl₂ / 0.5 h

4: 60 mg / TBAF / tetrahydrofuran / 1 h / -5 °C

5: NMO, tetrapropylammonium perruthenate / 0.75 h / Ambient temperature

With pyridine; dmap; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo9902042