sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate

Base Information

Chemical Name:sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate
CAS No.:1361001-56-0
Molecular Formula:C₂₄H₁₆FO₂*Na
Molecular Weight:378.378
Hs Code.:

Synonyms:sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate

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Chemical Property of sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate

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Technology Process of sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate

There total 2 articles about sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3218-36-8
4-Phenylbenzaldehyde

: 162548-68-7
ethyl 2-(6-fluoro-1-hydroxy-2,3-dihydro-1H-inden-1-yl)acetate

: 1361001-56-0
sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate

Guidance literature:: ethyl 2-(6-fluoro-1-hydroxy-2,3-dihydro-1H-inden-1-yl)acetate; With toluene-4-sulfonic acid; calcium chloride; In toluene; for 16h; Reflux;

4-Phenylbenzaldehyde; With sodium hydroxide; In methanol; at 20 - 70 ℃;

With hydrogenchloride; In water; at 20 ℃; pH=1 - 2;
DOI:10.1021/jm201528b

Reference yield:

: 1481-32-9
6-fluoroindan-1-one

: 1361001-56-0
sodium (E)-2-(1-([1,1'-biphenyl]-4-ylmethylene)-5-fluoro-1H-inden-3-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -75 °C / Inert atmosphere

1.2: 2 h / -75 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

2.2: 20 - 70 °C

2.3: 20 °C / pH 1 - 2

With toluene-4-sulfonic acid; calcium chloride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1021/jm201528b