{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

Base Information

Chemical Name:{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester
CAS No.:128308-13-4
Molecular Formula:C₅₀H₇₀O₉S
Molecular Weight:847.166
Hs Code.:

{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

Synonyms:{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

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Chemical Property of {(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

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Technology Process of {(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

There total 3 articles about {(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 128440-08-4
(3R,4R)-4-Benzyloxy-3-hydroxy-pentanethioic acid S-tert-butyl ester

: 128308-12-3
{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid

: 128308-13-4
{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; dmap; In diethyl ether; for 5h; Ambient temperature;
DOI:10.1016/S0040-4039(00)70661-7

Reference yield:

: 128308-10-1,128332-11-6
{(2S,3R,6S,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid methyl ester

: 128308-13-4
{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TsOH / CHCl₃ / 0.5 h / Ambient temperature

2: 94 percent / 0.5 N NaOH / tetrahydrofuran / Ambient temperature

3: 65 percent / DCC / DMAP / diethyl ether / 5 h / Ambient temperature

With sodium hydroxide; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; dmap; In tetrahydrofuran; diethyl ether; chloroform;
DOI:10.1016/S0040-4039(00)70661-7

Reference yield:

: 128308-10-1,128332-11-6
{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid methyl ester

: 128308-13-4
{(2S,3R,6R,8R,9S,10S)-8-[(1S,4S)-4-(3-Benzyloxy-phenyl)-4-methoxy-1-methyl-butyl]-10-hydroxy-3,5,5,9-tetramethyl-1,7-dioxa-spiro[5.5]undec-2-yl}-acetic acid (1R,2R)-2-benzyloxy-1-tert-butylsulfanylcarbonylmethyl-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / 0.5 N NaOH / tetrahydrofuran / Ambient temperature

2: 65 percent / DCC / DMAP / diethyl ether / 5 h / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; dmap; In tetrahydrofuran; diethyl ether;
DOI:10.1016/S0040-4039(00)70661-7