3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester

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Chemical Name:3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester
CAS No.:869997-43-3
Molecular Formula:C₃₇H₃₉N₃O₃
Molecular Weight:573.735
Hs Code.:

Synonyms:3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester

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Chemical Property of 3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester

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Technology Process of 3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester

There total 4 articles about 3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 269071-75-2
5-adamantan-1-yl-2,3-dioxopentanoic acid ethyl ester

: 869997-43-3
3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / NH₄OAc; AcOH / 2 h / 70 °C

2: 80 percent / aq. NaOH / ethanol / 24 h / Heating

3: 54 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine; 1-hydroxybenzotriazole / dimethylformamide / 72 h / 20 °C

With dmap; sodium hydroxide; ammonium acetate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0490686

Reference yield:

: 269071-81-0
5-(2-adamantan-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carboxylic acid ethyl ester

: 869997-43-3
3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aq. NaOH / ethanol / 24 h / Heating

2: 54 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine; 1-hydroxybenzotriazole / dimethylformamide / 72 h / 20 °C

With dmap; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0490686

Reference yield:

: 455333-76-3
5-adamantan-1-yl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)pentanoic acid ethyl ester

: 869997-43-3
3-{[5-(2-adamant-1-ylethyl)-2-o-tolyl-1H-imidazole-4-carbonyl]amino}benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / OXONE / tetrahydrofuran / 16 h / 20 °C

2: 56 percent / NH₄OAc; AcOH / 2 h / 70 °C

3: 80 percent / aq. NaOH / ethanol / 24 h / Heating

4: 54 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-(dimethylamino)pyridine; 1-hydroxybenzotriazole / dimethylformamide / 72 h / 20 °C

With dmap; Oxone; sodium hydroxide; ammonium acetate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0490686