trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

Base Information

Chemical Name:trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate
CAS No.:946000-02-8
Molecular Formula:C₃₁H₃₀ClF₂N₃O₄S
Molecular Weight:614.113
Hs Code.:

trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

Synonyms:trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

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Chemical Property of trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

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Technology Process of trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

There total 11 articles about trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 946000-01-7
trans-methyl 4-(3-{[[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

: 946000-02-8
trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

Guidance literature:: trans-methyl 4-(3-{[[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyl]-(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate; With methanol; acetyl chloride; at 0 ℃; for 2h;

With hydrogenchloride; In dichloromethane; water;

With sodium hydrogencarbonate; In water; pH=9;

Reference yield:

: 566172-81-4
3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl chloride

: 946000-02-8
trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

2.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; toluene / 3.25 - 6.25 h / 87 °C

3.1: methanol; acetyl chloride / 2 h / 0 °C

3.3: pH 9

With methanol; caesium carbonate; N-ethyl-N,N-diisopropylamine; acetyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; toluene; 2.1: Suzuki Coupling;

Reference yield:

: 566172-79-0
trans-N-methyl-N-tert-butoxycarbonyl-1,4-diaminocyclohexane

: 946000-02-8
trans-methyl 4-(3-{[(3-chloro-4,7-difluoro-benzo[b]thiophene-2-carbonyl)-(4-methylamino-cyclohexyl)-amino]-methyl}-4-methoxy-phenyl)-pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / tetrahydrofuran; methanol; toluene / 4 h / 20 °C

1.2: 1 h

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 20 °C

3.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; toluene / 3.25 - 6.25 h / 87 °C

4.1: methanol; acetyl chloride / 2 h / 0 °C

4.3: pH 9

With methanol; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; acetyl chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; toluene; 3.1: Suzuki Coupling;