4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate

Base Information

Chemical Name:4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate
CAS No.:917365-39-0
Molecular Formula:C₂₂H₂₂N₂O₈S
Molecular Weight:474.491
Hs Code.:

Synonyms:4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate

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Chemical Property of 4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate

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Technology Process of 4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate

There total 1 articles about 4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 118017-20-2
4-hydroxybut-2-yn-1-yl benzoate

: 198572-71-3
N-(tert-butoxycarbonyl)-2-nitrobenzenesulfonamide

: 917365-39-0
4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 48h;
DOI:10.1021/ja065724a

Reference yield: 66.0%

: 917365-39-0
4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate

: 214749-90-3
1-(tert-butoxycarbonylamino)-4-hydroxy-2-butyne

Guidance literature:: 4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate; With lithium hydroxide; mercaptoacetic acid; In N,N-dimethyl-formamide; for 2h;

In methanol; N,N-dimethyl-formamide; for 0.75h; Further stages.;
DOI:10.1021/ja065724a

Reference yield:

: 917365-39-0
4-(N-(tert-butoxycarbonyl)-2-nitrophenylsulfonamido)but-2-ynyl benzoate

: C₂₆H₂₉BrN₂O₆S

Guidance literature:: Multi-step reaction with 3 steps

1.1: thioglycolic acid; LiOH / dimethylformamide / 2 h

1.2: 66 percent / methanol; dimethylformamide / 0.75 h

2.1: 98 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran; toluene / 0 - 20 °C

3.1: 56 percent / [RuCl₂(=CHPh)(PCy)3)2] / benzene / Heating

With lithium hydroxide; mercaptoacetic acid; triphenylphosphine; diethylazodicarboxylate; [RuCl₂(=CHPh)(PCy)3)2]; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; benzene; 2.1: Fukuyama-Mitsunobu coupling reaction;
DOI:10.1021/ja065724a