N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide

Base Information

Chemical Name:N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide
CAS No.:553632-56-7
Molecular Formula:C₃₀H₃₅ClN₆O₂
Molecular Weight:547.1
Hs Code.:

Synonyms:N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide

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Chemical Property of N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide

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Technology Process of N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide

There total 9 articles about N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: N-{2-[2-phenyl-6-(piperidin-4-yloxymethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino]ethyl}acetamide trifluoroacetic acid salt

: 122-78-1
phenylacetaldehyde

: 553632-56-7
N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide

Guidance literature:: With sodium trimethoxyborohydride; In methanol; at 20 ℃;

Reference yield:

: 251947-25-8
4-chloro-6-methyl-2-phenylpyrrolo[2,3-d]pyrimidine-7-carboxylic acid tert-butyl ester

: 553632-56-7
N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Heating / reflux

2: silver trifluoroacetate / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 18 h / 20 °C

3: sodium hydrogencarbonate / dimethyl sulfoxide / 90 °C

4: trifluoroacetic acid / trifluoroacetic acid

5: sodium trimethoxyborohydride / methanol / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); silver trifluoroacetate; sodium trimethoxyborohydride; sodium hydrogencarbonate; trifluoroacetic acid; In methanol; tetrachloromethane; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide; trifluoroacetic acid;

Reference yield:

: 2-cyano-3-(2-methyl-[1,3]dioxolan-2-yl)-propionic acid methyl ester

: 553632-56-7
N-[2-(6-{1-[2-(3-chlorophenyl)ethyl]piperidin-4-yloxymethyl}-2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)ethyl]acetanilide

Guidance literature:: Multi-step reaction with 9 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / DMF (N,N-dimethyl-formamide) / 15 h / 85 °C

2: hydrogenchloride; water / 2 h / 20 °C

3: trichlorophosphate / 14 h / Heating / reflux

4: 2-(Dimethylamino)pyridine / pyridine / 20 h

5: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / Heating / reflux

6: silver trifluoroacetate / 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran / 18 h / 20 °C

7: sodium hydrogencarbonate / dimethyl sulfoxide / 90 °C

8: trifluoroacetic acid / trifluoroacetic acid

9: sodium trimethoxyborohydride / methanol / 20 °C

With hydrogenchloride; 2-(Dimethylamino)pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; silver trifluoroacetate; sodium trimethoxyborohydride; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; trichlorophosphate; In pyridine; methanol; tetrachloromethane; DMF (N,N-dimethyl-formamide); 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide; trifluoroacetic acid;