(1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

Base Information

Chemical Name:(1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester
CAS No.:1001096-88-3
Molecular Formula:C₁₄H₁₈F₂NO₂P
Molecular Weight:301.273
Hs Code.:

Synonyms:(1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

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Chemical Property of (1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

Chemical Property:

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Technology Process of (1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

There total 6 articles about (1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1001096-02-1
(1-benzyloxycarbonylamino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

: 1001096-88-3
(1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

Guidance literature:: (1-benzyloxycarbonylamino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester; With trimethylsilyl iodide; In acetonitrile; at 0 - 20 ℃; for 0.75h;

With triethylamine; In methanol; acetonitrile; at 0 - 20 ℃; for 0.333333h; Product distribution / selectivity;

Reference yield:

: 1001095-46-0
C₁₅H₂₀NO₄P

: 1001096-88-3
(1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 12.05 h / 40 °C / Inert atmosphere

2.1: dimethylsulfide; trifluoroacetic acid / 16 h / 20 °C

With chloro-trimethyl-silane; dimethylsulfide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.tetlet.2012.02.111

Reference yield:

: 877068-76-3
diethyl (1S,2S)-1-amino-2-vinyl-cyclopropane-1-phosphonate

: 1001096-88-3
(1-amino-2-vinyl-cyclopropyl)-(2,6-difluoro-benzyl)-phosphinic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 17 h / 20 °C

2.1: pyridine; sodium iodide / 5 h / Reflux

3.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 0 °C

4.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -78 - 20 °C

4.2: Cooling with ice

5.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

5.2: 12.05 h / 40 °C / Inert atmosphere

6.1: dimethylsulfide; trifluoroacetic acid / 16 h / 20 °C

With pyridine; chloro-trimethyl-silane; oxalyl dichloride; dimethylsulfide; sodium hydrogencarbonate; lithium tri-t-butoxyaluminum hydride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1016/j.tetlet.2012.02.111