(2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine

Base Information

Chemical Name:(2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine
CAS No.:911411-88-6
Molecular Formula:C₁₂H₁₇F₃N₂O
Molecular Weight:262.275
Hs Code.:

Synonyms:(2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine

Chemical Property:

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Technology Process of (2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine

There total 7 articles about (2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 911411-55-7
(2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methylpropionitrile

: 911411-88-6
(2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 24h;
DOI:10.1021/jo0607717

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 911411-88-6
(2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / pyridinium p-toluenesulfonate / toluene / 12 h / Heating

2: LDA / tetrahydrofuran / -78 °C

3: Yb(OTf)3 / CH₂Cl₂ / 0 - 20 °C

4: 98 percent / lithium aluminum hydride / diethyl ether / 24 h / 20 °C

With lithium aluminium tetrahydride; pyridinium p-toluenesulfonate; ytterbium(III) triflate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; toluene;
DOI:10.1021/jo0607717

Reference yield:

: 911411-43-3
((E)-2,2,2-trifluoro-1-methylethylidene)((1R)-2-hydroxy-1-phenylethyl)amine

: 911411-88-6
(2S)-3,3,3-trifluoro-2-((1R)-2-hydroxy-1-phenyl-ethylamino)-2-methyl-propylamine

Guidance literature:: Multi-step reaction with 2 steps

1: Yb(OTf)3 / CH₂Cl₂ / 0 - 20 °C

2: 98 percent / lithium aluminum hydride / diethyl ether / 24 h / 20 °C

With lithium aluminium tetrahydride; ytterbium(III) triflate; In diethyl ether; dichloromethane;
DOI:10.1021/jo0607717