4-Azido-7-(trifluoromethyl)quinoline

Base Information

• Chemical Name: 4-Azido-7-(trifluoromethyl)quinoline
• CAS No.: 74227-77-3
• Molecular Formula: C10H5 F3 N4
• Molecular Weight: 239.1761
• NSC Number: 377885
• DSSTox Substance ID: DTXSID60392251
• Wikidata: Q82190318
• Mol file: 74227-77-3.mol

Synonyms:74227-77-3;4-azido-7-(trifluoromethyl)quinoline;DTXSID60392251;NSC377885;NSC-377885

Chemical Property of 4-Azido-7-(trifluoromethyl)quinoline

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 238.04663066
• Heavy Atom Count: 17
• Complexity: 324

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=CN=C2C=C1C(F)(F)F)N=[N+]=[N-]

Technology Process of 4-Azido-7-(trifluoromethyl)quinoline

There total 2 articles about 4-Azido-7-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-chloro-7-trifluoromethyl quinoline (346-55-4) → 4-azido-7-(trifluoromethyl)quinoline (74227-77-3)

Guidance literature:

With sodium azide; In ethanol; water; Heating;

DOI:10.1248/cpb.28.1485

Reference yield:

(7-Trifluoromethyl-quinolin-4-yl)-hydrazine → 4-azido-7-(trifluoromethyl)quinoline (74227-77-3)

Guidance literature:

With hydrogenchloride; sodium nitrite; at 0 - 5 ℃;

Reference yield: 65.0%

4-azido-7-(trifluoromethyl)quinoline (74227-77-3) → 7-trifluoromethyl-quinolin-4-ylamine (243666-11-7)

Guidance literature:

With water; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2013.04.040

upstream raw materials:

4-chloro-7-trifluoromethyl quinoline

Downstream raw materials:

2-diazo-3-oxo-N-phenylbutanamide

7-trifluoromethyl-quinolin-4-ylamine

antrafenine