Technology Process of ethyl 1-(4-carboethoxy-4R-phenethylbutanoyl)-indoline-2S-carboxylate
There total 8 articles about ethyl 1-(4-carboethoxy-4R-phenethylbutanoyl)-indoline-2S-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetyl chloride / 2 h / 50 °C
2: 3 h / Heating
3: triethylamine, 1-<3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2 / Ambient temperature
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; acetyl chloride;
In
dichloromethane;
DOI:10.1021/jm00363a012
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90 percent / 1 N aq. NaOH / CH2Cl2 / a) 0 deg C, 4 h, b) RT, 1 h
2: 1.) lithium diisopropylamide / 1.) THF, 0 deg C, 30 min, 2.) THF, a) 0 deg C, 5 h, b) -15 deg C, 15 h
3: 10percent ethanolic sulfuric acid
5: triethylamine, 1-<3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2 / Ambient temperature
With
sodium hydroxide; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide;
In
dichloromethane;
DOI:10.1021/jm00363a012
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 3 h / Heating
2: triethylamine, 1-<3-(dimethylamino)propyl)-3-ethylcarbodiimide hydrochloride / CH2Cl2 / Ambient temperature
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane;
DOI:10.1021/jm00363a012
