1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene

Base Information

Chemical Name:1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene
CAS No.:223654-80-6
Molecular Formula:C₄₁H₄₀O₃Si
Molecular Weight:608.852
Hs Code.:

Synonyms:1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene

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Chemical Property of 1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene

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Technology Process of 1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene

There total 6 articles about 1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.5%

: 223654-79-3
2-[4-(3-bromo-phenylethynyl)-phenoxy]-tetrahydro-pyran

: 148455-06-5
[4-[[(1,1-dimethylethyl)diphenylsilyl] oxy]phenyl]-boronic acid

: 223654-80-6
1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In benzene; for 4h; Heating;
DOI:10.1039/a808275h

Reference yield:

: 36603-49-3
4-(tetrahydropyran-2'-yloxy)-1-bromobenzene

: 223654-80-6
1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene

Guidance literature:: Multi-step reaction with 4 steps

1: Pd(PPh₃)4; CuI; Et₃N

2: KOH; MeOH

3: Pd(PPh₃)4; Et₃N; CuI

4: Pd(PPh₃)4; Na₂CO₃ / benzene; H₂O

With methanol; potassium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In water; benzene; 1: Addition / 2: Elimination / 3: Addition / 4: Addition;
DOI:10.1021/ja993572w

Reference yield:

: 119754-16-4
[4-(tetrahydropyran-2-yloxy)phenyl]ethyne

: 223654-80-6
1-<4-(tert-butyldiphenylsilyloxy)phenyl>-3-(4-tetrahydropyranyloxyphenylethynyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: Pd(PPh₃)4; Et₃N; CuI

2: Pd(PPh₃)4; Na₂CO₃ / benzene; H₂O

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; triethylamine; In water; benzene; 1: Addition / 2: Addition;
DOI:10.1021/ja993572w