(1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine

Base Information

• Chemical Name: (1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine
• CAS No.: 691905-84-7
• Molecular Formula: C₄₃H₄₅NO₅
• Molecular Weight: 655.834
• Mol file: 691905-84-7.mol

Synonyms:(1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine

Chemical Property of (1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine

There total 2 articles about (1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

(2S,3S)-4-[(2R,3S,4R)-3,4-bis(benzyloxy)pyrrolidin-2-yl]-2,3,4-tris(benzyloxy)butan-1-ol → (1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine (691905-84-7)

Guidance literature:

With carbon tetrabromide; triethylamine; triphenylphosphine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo049806y

Reference yield: 54.0%

tert-butyl (2R,3S,4R)-3,4-bis(benzyloxy)-2-[(1R,2S,3S)-1,2,3-tris(benzyloxy)-4-(triphenylmethyloxy)butyl]pyrrolidine-1-carboxylate (691905-82-5) → (1S,2R,6S,7R,8R,8aR)-1,2,6,7,8-pentakis(benzyloxy)octahydroindolizine (691905-84-7) + (2S,3S)-4-[(2R,3S,4R)-3,4-bis(benzyloxy)pyrrolidin-2-yl]-2,3,4-tris(benzyloxy)butan-1-ol

Guidance literature:

With methoxybenzene; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo049806y

upstream raw materials:

tert-butyl (2R,3S,4R)-3,4-bis(benzyloxy)-2-[(1R,2S,3S)-1,2,3-tris(benzyloxy)-4-(triphenylmethyloxy)butyl]pyrrolidine-1-carboxylate