Technology Process of (2R,3R)-2-bezyloxymethyl-3-[(E)-pentadec-1-enyl]oxirane
There total 5 articles about (2R,3R)-2-bezyloxymethyl-3-[(E)-pentadec-1-enyl]oxirane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
Oxone; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate;
4,5-O-Me2C-3-oxo-THP-2-spiro-4'-2',2'-Me2-1',3'-dioxolan;
In
water; acetonitrile;
for 1.5h;
DOI:10.1021/jo0268254
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2.7 g / LiOH*H2O; 4 Angstroem molecular sieves / tetrahydrofuran / 2.5 h / Heating
2: 59 percent / DIBALH / CH2Cl2; hexane / 1.5 h / -40 °C
3: 95 percent / NaH; Bu4NI / tetrahydrofuran / 48 h / Heating
4: 25 percent / Bu4NHSO4; Oxone; K2CO3 / 4,5-O-Me2C-3-oxo-THP-2-spiro-4'-2',2'-Me2-1',3'-dioxolan / acetonitrile; various solvent(s); H2O / 1.5 h
With
Oxone; lithium hydroxide; 4 A molecular sieve; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate;
4,5-O-Me2C-3-oxo-THP-2-spiro-4'-2',2'-Me2-1',3'-dioxolan;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
1: Wittig reaction;
DOI:10.1021/jo0268254
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 59 percent / DIBALH / CH2Cl2; hexane / 1.5 h / -40 °C
2: 95 percent / NaH; Bu4NI / tetrahydrofuran / 48 h / Heating
3: 25 percent / Bu4NHSO4; Oxone; K2CO3 / 4,5-O-Me2C-3-oxo-THP-2-spiro-4'-2',2'-Me2-1',3'-dioxolan / acetonitrile; various solvent(s); H2O / 1.5 h
With
Oxone; tetra(n-butyl)ammonium hydrogensulfate; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; potassium carbonate;
4,5-O-Me2C-3-oxo-THP-2-spiro-4'-2',2'-Me2-1',3'-dioxolan;
In
tetrahydrofuran; hexane; dichloromethane; water; acetonitrile;
DOI:10.1021/jo0268254