5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride

Base Information

• Chemical Name: 5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride
• CAS No.: 1042738-15-7
• Molecular Formula: C₃₅H₃₄N₂O₄*ClH
• Molecular Weight: 583.127
• Mol file: 1042738-15-7.mol

Synonyms:5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride

Chemical Property of 5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride

There total 1 articles about 5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one (100331-89-3) + (R)-(-)-1-(4'-methoxyphenyl)-2-benzylaminopropane (67346-60-5) → 5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride (1042738-15-7)

Guidance literature:

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; (R)-(-)-1-(4'-methoxyphenyl)-2-benzylaminopropane; With sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide; Heating / reflux;

With hydrogenchloride; In chloroform; water;

Reference yield: 86.0%

5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride (1042738-15-7) → (5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]-(phenylmethyl)amino]ethyl]-8-phenylmethoxy)-2(1H)-quinolinone monohydrochloride

Guidance literature:

5-[[[(1R)-2-(4-methoxyphenyl)-1-methylethyl](phenylmethyl)amino]acetyl]-8-(phenylmethoxy)-(1H)-quinolin-2-one monohydrochloride; With sodium tetrahydroborate; In methanol; dichloromethane; at -60 - -40 ℃; for 0.5h;

In methanol; dichloromethane; at -10 - 10 ℃;

With hydrogenchloride; In chloroform; water;

upstream raw materials:

8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one

(R)-(-)-1-(4'-methoxyphenyl)-2-benzylaminopropane