Technology Process of (Z)-5'-(2-chlorobenzylidene)-1-ethyl-5,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one
There total 5 articles about (Z)-5'-(2-chlorobenzylidene)-1-ethyl-5,6-dimethoxy-5'H-spiro-[indoline-3,2'-thiophen]-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid;
In
toluene;
at 90 ℃;
for 12h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/jo301039y
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulfuryl dichloride / Reflux; Inert atmosphere
2: triethylamine / dichloromethane / Inert atmosphere
3: sodium tetrahydroborate / methanol / Inert atmosphere
4: copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid / toluene / 12 h / 90 °C / Inert atmosphere
With
sodium tetrahydroborate; sulfuryl dichloride; copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid; triethylamine;
In
methanol; dichloromethane; toluene;
DOI:10.1021/jo301039y
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / Inert atmosphere
2: copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid / toluene / 12 h / 90 °C / Inert atmosphere
With
sodium tetrahydroborate; copper(ll) sulfate pentahydrate; toluene-4-sulfonic acid;
In
methanol; toluene;
DOI:10.1021/jo301039y
