(3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one

Base Information

Chemical Name:(3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one
CAS No.:1399859-37-0
Molecular Formula:C₁₉H₂₀N₂O₃
Molecular Weight:324.379
Hs Code.:

Synonyms:(3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one

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Chemical Property of (3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one

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Technology Process of (3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one

There total 2 articles about (3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1399859-31-4
(3R, 8aS)-benzylhexahydro-8a-(4-methoxyphenyl)-5-oxo-3-phenyloxazolo[3,2-a]pyrazine-7-carboxylate

: 1399859-37-0
(3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one

Guidance literature:: With 20% Pd/C; hydrogen; In ethanol; at 20 ℃; for 20h; stereoselective reaction;
DOI:10.1016/j.tetlet.2012.07.031

Reference yield:

: C₁₂H₁₅NO₄

: 1399859-37-0
(3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrahydrofuran / 20 h / 0 - 20 °C

2: lithium hydroxide / tetrahydrofuran / 3 h / 20 °C

3: D-2-phenylglycinol; (1S)-10-camphorsulfonic acid / toluene / 20 h / Reflux; Dean-Stark

4: 20% Pd/C; hydrogen / ethanol / 20 h / 20 °C

With 20% Pd/C; (1S)-10-camphorsulfonic acid; D-2-phenylglycinol; hydrogen; sodium carbonate; lithium hydroxide; In tetrahydrofuran; ethanol; toluene;
DOI:10.1016/j.tetlet.2012.07.031

Reference yield:

: 1399859-37-0
(3R, 8aS)-hexahydro-8a-(4-methoxyphenyl)-3-phenyloxazolo[3,2-a]pyrazin-5-one

: 1399859-42-7
C₁₉H₂₄N₂O₂

: 1399859-43-8
C₁₉H₂₄N₂O₂

Guidance literature:: With aluminum (III) chloride; lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 2h; Optical yield = 60 %de; stereoselective reaction;
DOI:10.1016/j.tetlet.2012.07.031