4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline

Base Information

• Chemical Name: 4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline
• CAS No.: 1027818-88-7
• Molecular Formula: C₆H₂ClF₃IN
• Molecular Weight: 307.441
• Hs Code.: 2933399990
• Mol file: 1027818-88-7.mol

Synonyms:4-chloro-5-iodo-2-(trifluoromethyl)pyridine

Chemical Property of 4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4-Chloro-5-iodo-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Chloro-5-iodo-2-(trifluoromethyl)pyridine is a useful reactant in the synthesis of therapeuticagents.

Technology Process of 4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline

There total 1 articles about 4-Chloro-5-iodo-alpha,alpha,alpha-trifluoro-2-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-iodo-2-(trifluoromethyl)-pyridin-4-ol (1027818-89-8) → 4-chloro-5-iodo-2-(trifluoromethyl)pyridine (1027818-88-7)

Guidance literature:

With trichlorophosphate; at 100 ℃; for 1.5h;

Reference yield: 40.0%

4-chloro-5-iodo-2-(trifluoromethyl)pyridine (1027818-88-7) + tert-butyl 2-(2,6-difluorophenyl)-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine-1-carboxylate → C24H21ClF5N3O2

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 110 ℃; for 16h; Inert atmosphere;

Reference yield:

4-chloro-5-iodo-2-(trifluoromethyl)pyridine (1027818-88-7) → 2-(2,6-difluorophenyl)-5-[4-methoxy-6-(trifluoromethyl)pyridin-3-yl]-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere

2: sodium methylate / methanol / 2 h / Reflux

With sodium methylate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In methanol; toluene;

upstream raw materials:

5-iodo-2-(trifluoromethyl)-pyridin-4-ol

Downstream raw materials:

5-iodo-2-(trifluoromethyl)pyridin-4-amine

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