methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate
• CAS No.: 1612148-78-3
• Molecular Formula: C₁₉H₁₇FN₂O₄
• Molecular Weight: 356.353

Synonyms:methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

Chemical Property of methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

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Technology Process of methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate

There total 4 articles about methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

methyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutanoate sodium salt + 4-fluorophenyhydrazine hydrochloride (823-85-8) → methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (1612148-78-3) + methyl 3-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-5-carboxylate

Guidance literature:

With hydrogenchloride; acetic acid; In water; for 3.5h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2016.06.018

Reference yield: 55.0%

methyl 4-(2,6-dimethoxyphenyl)-2,4-dioxobutanoate sodium salt + 4-fluorophenyhydrazine hydrochloride (823-85-8) → methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (1612148-78-3)

Guidance literature:

With hydrogenchloride; acetic acid; In water; Inert atmosphere; Reflux;

DOI:10.1021/jm5003843

Reference yield: 55.0%

→ methyl 5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylate (1612148-78-3)

Guidance literature:

With hydrogenchloride; acetic acid; for 5h; Reflux; Inert atmosphere;

upstream raw materials:

4-fluorophenyhydrazine hydrochloride

2,6-dimethoxyacetophenone

Downstream raw materials:

5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid

2-({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)tricycle-[3.3.1.13,7]decane-2-carboxylic acid

methyl 1-({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylate

1-({[5-(2,6-dimethoxyphenyl)-1-(4-fluorophenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexanecarboxylic acid

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