(S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid

Base Information

Chemical Name:(S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid
CAS No.:1584150-14-0
Molecular Formula:C₁₅H₁₉F₂N₃O₆
Molecular Weight:375.329
Hs Code.:

Synonyms:(S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid

Chemical Property:

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Technology Process of (S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid

There total 2 articles about (S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1214352-95-0
1-(difluoromethyl)-3-fluoro-2-nitrobenzene

: 76387-70-7
(S)-3-amino-2-tert-butoxycarbonylaminopropionic acid

: 1584150-14-0
(S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid

Guidance literature:: With potassium carbonate; In ethanol; at 85 ℃; Inert atmosphere;

Reference yield:

: 872366-63-7
3-fluoro-2-nitrobenzaldehyde

: 1584150-14-0
(S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 1.08 h / -78 - 20 °C

2: potassium carbonate / ethanol / 85 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; potassium carbonate; In ethanol; dichloromethane;

Reference yield:

: 1584150-14-0
(S)-2-((tert-butoxycarbonyl)amino)-3-((3-(difluoromethyl)-2-nitrophenyl)amino)propanoic acid

: 1584150-15-1
(S)-3-((2-amino-3-(difluoromethyl)phenyl)amino)-2-((tertbutoxycarbonyl)amino)propanoic acid

Guidance literature:: With palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; In methanol; at 20 ℃; for 1.41667h; Inert atmosphere;