(2R,3S)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide

Base Information

Chemical Name:(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide
CAS No.:104947-02-6
Molecular Formula:C₃₅H₅₇NO₂SSi₂
Molecular Weight:612.08
Hs Code.:

Synonyms:(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide

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Technology Process of (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide

There total 7 articles about (2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 6621-59-6
6-bromo-1-hexanenitrile

: 104946-98-7
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>-1-pentanethiol

: 104947-02-6
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide

Guidance literature:: With potassium hydride; In tetrahydrofuran; at -78 - 20 ℃; for 1.25h;
DOI:10.1021/jm00384a026

Reference yield:

: 4390-94-7
1,2-bis(4-methoxyphenyl)butanone

: 104947-02-6
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / NaH, EtSH / dimethylformamide / 19 h / 120 °C

2: 89 percent / imidazole / dimethylformamide / 1 h

3: diethyl ether; hexane / 20 h / Ambient temperature

4: 1.) BH₃*THF, 2.) H₂O, NaOH, H₂O₂ / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h

5: 76 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C

6: 58 percent / LiAlH₄ / diethyl ether / 0.08 h / 0 °C

7: 58 percent / KH / tetrahydrofuran / 1.25 h / -78 - 20 °C

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; potassium hydride; sodium hydride; triphenylphosphine; ethanethiol; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026

Reference yield:

: 76579-69-6
1,2-bis-(4-hydroxy-phenyl)-butan-1-one

: 104947-02-6
(2R*,3S*)-2,3-bis<4-<(tert-butyldimethylsilyl)oxy>phenyl>pentyl 5-cyanopentyl sulfide

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / imidazole / dimethylformamide / 1 h

2: diethyl ether; hexane / 20 h / Ambient temperature

3: 1.) BH₃*THF, 2.) H₂O, NaOH, H₂O₂ / 1.) THF, 0 deg C, 4.5 h, 2.) THF, from 45 to 50 deg C, 1 h

4: 76 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran / 5 h / 0 °C

5: 58 percent / LiAlH₄ / diethyl ether / 0.08 h / 0 °C

6: 58 percent / KH / tetrahydrofuran / 1.25 h / -78 - 20 °C

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; borane-THF; di-isopropyl azodicarboxylate; water; dihydrogen peroxide; potassium hydride; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm00384a026