3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

Base Information

Chemical Name:3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide
CAS No.:1053735-60-6
Molecular Formula:C₄₃H₄₃N₅O₆
Molecular Weight:725.844
Hs Code.:

3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

Synonyms:3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

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Chemical Property of 3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

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Technology Process of 3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

There total 5 articles about 3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1603-41-4
(5-methyl-pyridin-2-yl)amine

: 1054795-51-5
3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-benzoic acid methyl ester

: 1053735-60-6
3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

Guidance literature:: With trimethylaluminum; In 1,2-dichloro-ethane; for 24h; Heating;
DOI:10.1021/jm970288b

Reference yield:

: 1129-28-8
3-methoxycarbonylbenzyl bromide

: 1053735-60-6
3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 48 h

2: 54 percent / acetonitrile / 72 h / Heating

3: 35 percent / trimethylaluminum / 1,2-dichloro-ethane / 24 h / Heating

With trimethylaluminum; sodium hydride; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm970288b

Reference yield:

: 170028-72-5
(3aS,4R,8R,8aS)-4,8-dibenzyl-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-e][1,3]diazepin-6(7H)-one

: 1053735-60-6
3-[(3aS,4R,8R,8aS)-4,8-Dibenzyl-2,2-dimethyl-7-(3-nitro-benzyl)-6-oxo-hexahydro-1,3-dioxa-5,7-diaza-azulen-5-ylmethyl]-N-(5-methyl-pyridin-2-yl)-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 1,2-dichloro-ethane / 16 h / Heating

2: 1.) NaH / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, 48 h

3: 54 percent / acetonitrile / 72 h / Heating

4: 35 percent / trimethylaluminum / 1,2-dichloro-ethane / 24 h / Heating

With trimethylaluminum; sodium hydride; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/jm970288b