methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate

Base Information

Chemical Name:methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate
CAS No.:1033693-66-1
Molecular Formula:C₂₅H₃₁N₅O₃
Molecular Weight:449.553
Hs Code.:

Synonyms:methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate

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Chemical Property of methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate

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Technology Process of methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate

There total 1 articles about methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 216144-45-5
(4-(4-methylpiperazin-1-yl)phenyl)methanamine

: 1033693-65-0
methyl 4-(2-chloro-4-oxoquinazolin-3(4H)-yl)butanoate

: 1033693-66-1
methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate

Guidance literature:: (4-(4-methylpiperazin-1-yl)phenyl)methanamine; methyl 4-(2-chloro-4-oxoquinazolin-3(4H)-yl)butanoate; With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In diethyl ether; ethyl acetate;

Reference yield: 81.0%

: 1033693-66-1
methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate

: 1033693-67-2
4-[2-{[4-(4-methylpiperazin-1-yl)benzyl]amino}-4-oxoquinazolin-3(4H)-yl]butanoic acid

Guidance literature:: methyl 4-[2-[4-(4-methylpiperazin-1-yl)benzyl]amino-4-oxoquinazolin-3(4H)-yl]butanoate; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 2h;

With acetic acid; In water;