4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline

Base Information

• Chemical Name: 4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline
• CAS No.: 1207089-03-9
• Molecular Formula: C₁₃H₁₀ClF₆N₃
• Molecular Weight: 357.686
• Mol file: 1207089-03-9.mol

Synonyms:4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline

Chemical Property of 4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline

There total 4 articles about 4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-{[3,5-bis(trifluoro-methyl)-1H-pyrazol-1-yl]methyl}-2-methylaniline (866638-67-7) → 4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline (1207089-03-9)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

Reference yield:

1-(3-methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole (866638-66-6) → 4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline (1207089-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid / 5 h / 40 °C

2: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 60 °C

With N-chloro-succinimide; iron; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

4-(chloromethyl)-2-methyl-1-nitro-benzene (18515-14-5) → 4-{[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2-chloro-6-methylaniline (1207089-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

2: iron; acetic acid / 5 h / 40 °C

3: N-chloro-succinimide / N,N-dimethyl-formamide / 2 h / 60 °C

With N-chloro-succinimide; iron; potassium carbonate; acetic acid; In N,N-dimethyl-formamide;

upstream raw materials:

4-{[3,5-bis(trifluoro-methyl)-1H-pyrazol-1-yl]methyl}-2-methylaniline

4-(chloromethyl)-2-methyl-1-nitro-benzene

1-(3-methyl-4-nitrobenzyl)-3,5-bis(trifluoromethyl)-1H-pyrazole

3,5-bis(trifluoromethyl)pyrazole