Technology Process of (2R,3S)-2-Hydroxymethyl-3-phenylmethyloxirane
There total 6 articles about (2R,3S)-2-Hydroxymethyl-3-phenylmethyloxirane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; 4 A molecular sieve; D-(-)-diisopropyl tartrate;
In
dichloromethane;
at -20 ℃;
for 24h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 87 percent / 18-crown-6, KHMDS / tetrahydrofuran / 1.) -78 deg C, 5 min, 2.) -78 deg C, 50 min
2: 99 percent / DIBALH / CH2Cl2 / 0.25 h / -78 °C
3: 4 Angstroem molecular sieves, (-)-diisopropyl-D-tartrate, titanium(IV) isopropoxide, t-BuOOH / CH2Cl2; decane / 20 h / -20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; 18-crown-6 ether; 4 A molecular sieve; potassium hexamethylsilazane; diisobutylaluminium hydride; D-(-)-diisopropyl tartrate;
In
tetrahydrofuran; decane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / NaHMDS / CH2Cl2; tetrahydrofuran / 1 h / 22 °C
2: 90 percent / TBAF / tetrahydrofuran / 0.5 h / 0 °C
3: 4 Angstroem molecular sieves, (-)-diisopropyl-D-tartrate, titanium(IV) isopropoxide, t-BuOOH / CH2Cl2; decane / 20 h / -20 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; 4 A molecular sieve; tetrabutyl ammonium fluoride; sodium hexamethyldisilazane; D-(-)-diisopropyl tartrate;
In
tetrahydrofuran; decane; dichloromethane;
