2,4-Dimethyl-1,3-thiazole-5-carbohydrazide

Base Information

• Chemical Name: 2,4-Dimethyl-1,3-thiazole-5-carbohydrazide
• CAS No.: 99357-25-2
• Molecular Formula: C6H9 N3 O S
• Molecular Weight: 171.22
• European Community (EC) Number: 671-518-8
• DSSTox Substance ID: DTXSID00372496
• Wikidata: Q82160238
• Mol file: 99357-25-2.mol

Synonyms:99357-25-2;2,4-dimethylthiazole-5-carbohydrazide;2,4-dimethyl-1,3-thiazole-5-carbohydrazide;2,4-Dimethyl-thiazole-5-carboxylic acid hydrazide;dimethyl-1,3-thiazole-5-carbohydrazide;5-Thiazolecarboxylicacid, 2,4-dimethyl-, hydrazide;Maybridge1_008533;Oprea1_757233;SCHEMBL405248;HMS565L19;DTXSID00372496;WHGDPVYDXLQXON-UHFFFAOYSA-N;CCG-49414;MFCD00832910;AKOS003403421;SB86014;AS-68466;FT-0642397;W18794;2,4-Dimethylthiazole-5-carboxylic acid hydrazide;5-Thiazolecarboxylicacid,2,4-dimethyl-,hydrazide;A846011;SR-01000638868-1

Chemical Property of 2,4-Dimethyl-1,3-thiazole-5-carbohydrazide

Chemical Property:

• Melting Point: 124-126掳C
• PSA: 96.25000
• Density: 1.295g/cm³
• LogP: 1.45460
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 171.04663309
• Heavy Atom Count: 11
• Complexity: 164

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dimethyl-thiazole-5-carboxylic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC(=N1)C)C(=O)NN

Technology Process of 2,4-Dimethyl-1,3-thiazole-5-carbohydrazide

There total 1 articles about 2,4-Dimethyl-1,3-thiazole-5-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate (7210-77-7) → 2,4-dimethyl-thiazole-5-carboxylic acid hydrazide (99357-25-2)

Guidance literature:

With hydrazine hydrate; at 77 - 83 ℃; for 10h;

DOI:10.1134/S1070427208030385

Reference yield:

2,4-dimethyl-thiazole-5-carboxylic acid hydrazide (99357-25-2) + 3-fluoro-4-(α-D-mannopyranosyloxy)benzaldehyde → N'-[3-fluoro-4-(α-D-mannopyranosyloxy)benzylidene]-2,4-dimethylthiazole-5-carbohydrazide + N'-[3-fluoro-4-(α-D-mannopyranosyloxy)benzylidene]-2,4-dimethylthiazole-5-carbohydrazide

Guidance literature:

With acetic acid; In water; acetonitrile; at 20 ℃; Reagent/catalyst; Overall yield = 21%; Overall yield = 3.2mg;

DOI:10.24820/ark.5550190.p010.913

Reference yield:

2,4-dimethyl-thiazole-5-carboxylic acid hydrazide (99357-25-2) → 3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-phenylmethanesulfonyl)-4-naphthalen-2-yl-4H-[1,2,4]triazole

Guidance literature:

Multi-step reaction with 4 steps

1.1: 76 percent / aq. NaOH / ethanol / 3 h

2.1: 71 percent / NaHCO₃ / H₂O / 12 h / 120 - 140 °C

3.1: KOH / ethanol / 0.5 h

3.2: 86 percent / ethanol / 4 h / 20 °C

4.1: 76 percent / MCPBA / CH₂Cl₂ / 2.5 h / 0 - 20 °C

With potassium hydroxide; sodium hydroxide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water;

DOI:10.1002/1521-4184(200010)333:10<347::AID-ARDP347>3.0.CO;2-6

upstream raw materials:

ethyl 2,4-dimethyl-1,3-thiazole-5-carboxylate

Downstream raw materials:

5-(2,4-dimethyl-thiazol-5-yl)-[1,3,4]oxadiazol-2-ylamine

1-(2,4-dimethyl-thiazole-5-carbonyl)-4-phenyl-thiosemicarbazide

4-butyl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-methoxy-benzylsulfanyl)-4H-[1,2,4]triazole

4-butyl-3-(2,4-dimethyl-thiazol-5-yl)-5-(4-trifluoromethyl-benzylsulfanyl)-4H-[1,2,4]triazole