N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea

Base Information

• Chemical Name: N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea
• CAS No.: 852675-19-5
• Molecular Formula: C₁₀H₁₅N₃O₄S₃
• Molecular Weight: 337.445
• Mol file: 852675-19-5.mol

Synonyms:N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea

Chemical Property of N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea

There total 4 articles about N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Ethyl isothiocyanate (542-85-8) + 2-amino-5-(methylsulfonyl)benzenesulfonamide (7409-84-9) → N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea (852675-19-5)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Heating;

DOI:10.1021/jm0311339

Reference yield:

2-chloro-5-(methylsulfonyl)benzenesulfonamide (3544-47-6) → N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea (852675-19-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. ammonia / 2 h / 140 °C

2: 60 percent / K₂CO₃ / acetone / 4 h / Heating

With ammonium hydroxide; potassium carbonate; In acetone;

DOI:10.1021/jm0311339

Reference yield:

2-chloro-5-methanesulfonyl-benzenesulfonyl chloride (90084-62-1) → N-(2-amino-5-methylsulfonylbenzenesulfonyl)-N'-ethylthiourea (852675-19-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 3.54 g / aq. ammonia / 0.5 h

2: 90 percent / aq. ammonia / 2 h / 140 °C

3: 60 percent / K₂CO₃ / acetone / 4 h / Heating

With ammonium hydroxide; potassium carbonate; In acetone;

DOI:10.1021/jm0311339

upstream raw materials:

Ethyl isothiocyanate

2-amino-5-(methylsulfonyl)benzenesulfonamide

2-chloro-5-(methylsulfonyl)benzenesulfonamide

2-chloro-5-methanesulfonyl-benzenesulfonyl chloride