4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol)

Base Information

• Chemical Name: 4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol)
• CAS No.: 1360605-46-4
• Molecular Formula: C₂₄H₂₆O₇
• Molecular Weight: 426.466
• Mol file: 1360605-46-4.mol

Synonyms:4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol)

Chemical Property of 4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol)

There total 16 articles about 4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl 2,3,3-tri-(4-hydroxy-3-methoxyphenyl)propanoate (1415803-96-1) → 4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol) (1360605-46-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2013.07.048

Reference yield: 67.0%

2,3,3-tris(4-(benzyloxy)-3-methoxyphenyl)propan-1-ol (1415804-01-1) → 4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol) (1360605-46-4)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; In methanol; ethyl acetate; at 0.3 ℃; for 16h;

DOI:10.1016/j.bmcl.2013.07.058

Reference yield:

ethyl 4-hydroxy-3-methoxymandelate (52058-11-4) → 4,4',4''-(3-hydroxypropane-1,1,2-triyl)tris(2-methoxyphenol) (1360605-46-4)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate / acetone / 0.08 h / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: Dess-Martin periodane / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 12 h / 20 °C / Inert atmosphere

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium phosphate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene / 12 h / 110 °C / Inert atmosphere

5.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 50 °C / 14790.8 Torr

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; carbon tetrabromide; palladium 10% on activated carbon; hydrogen; potassium carbonate; Dess-Martin periodane; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; 4.1: |Suzuki-Miyaura Coupling;

DOI:10.1016/j.tetlet.2013.07.048

upstream raw materials:

ethyl 2,3,3-tri-(4-hydroxy-3-methoxyphenyl)propanoate

4-hydroxy-3-methoxy-mandelic acid

4-bromoguaiacol

ethyl 4-hydroxy-3-methoxymandelate