(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Base Information

Chemical Name:(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate
CAS No.:1370547-46-8
Molecular Formula:C₄₆H₇₁NO₆
Molecular Weight:734.073
Hs Code.:

(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Synonyms:(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Suppliers and Price of (1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

There total 7 articles about (1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1370547-45-7
(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-3-methoxy-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

: 108-24-7
acetic anhydride

: 1370547-46-8
(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; acetic acid; In Isopropyl acetate; at 20 - 60 ℃; for 3.5h; Large scale reaction;
DOI:10.1021/jo300046v

Reference yield:

: 388094-93-7
C₃₈H₆₀O₁₁

: 1370547-46-8
(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sulfuric acid / 14 h / Reflux; Large scale reaction

2: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 - 78 °C / Large scale reaction

3: potassium 2-methylbutan-2-olate / N,N-dimethyl acetamide; toluene / 24.5 h / 20 - 25 °C / Large scale reaction

4: toluene-4-sulfonic acid; acetic acid / Isopropyl acetate / 3.5 h / 20 - 60 °C / Large scale reaction

With sulfuric acid; potassium 2-methylbutan-2-olate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In N,N-dimethyl acetamide; Isopropyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo300046v

Reference yield:

: 1140751-11-6
(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-2-hydroxy-3-methoxy-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradeca-hydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylic acid

: 1370547-46-8
(1S,2R,3R,4aR,6aS,7R,8R,10aR,10bR,12aR)-benzyl 3-acetoxy-2-((S)-2,3-dimethyl-2-(methylamino)butoxy)-1,6a,8,10a-tetramethyl-8-((R)-3-methylbutan-2-yl)-2,3,4,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-1H-1,4a-(methanooxymethano)chrysene-7-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 25 - 78 °C / Large scale reaction

2: potassium 2-methylbutan-2-olate / N,N-dimethyl acetamide; toluene / 24.5 h / 20 - 25 °C / Large scale reaction

3: toluene-4-sulfonic acid; acetic acid / Isopropyl acetate / 3.5 h / 20 - 60 °C / Large scale reaction

With potassium 2-methylbutan-2-olate; potassium carbonate; toluene-4-sulfonic acid; acetic acid; In N,N-dimethyl acetamide; Isopropyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo300046v