N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea

Base Information

Chemical Name:N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea
CAS No.:1395051-21-4
Molecular Formula:C₂₅H₂₅ClN₈OS
Molecular Weight:521.046
Hs Code.:

Synonyms:N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea

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Chemical Property of N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea

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Technology Process of N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea

There total 6 articles about N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₀H₃₃ClN₈O₃S

: 1395051-21-4
N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

: 1395052-25-1
N₂-(6-chloro-2-methyl-4-pyrimidinyl)-5-(4-aminophenyl)-1,3-thiazol-2-amine

: 1395051-21-4
N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 2 h / 80 °C

2: pyridine / 2 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

: 90349-87-4
5-(4-aminophenyl)-2-amino-1,3-thiazole

: 1395051-21-4
N-(3-chlorophenyl)-N'-(4-2-[(2-methyl-6-piperazino-4-pyrimidinyl)amino]-1,3-thiazol-5-ylphenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 4 h / 0 - 20 °C

2: pyridine / 2 h / 80 °C

3: pyridine / 2 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

With pyridine; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; mineral oil;
DOI:10.1016/j.ejmech.2015.05.008