1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea

Base Information

Chemical Name:1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea
CAS No.:132981-02-3
Molecular Formula:C₂₀H₁₇F₃N₄O₃S
Molecular Weight:450.441
Hs Code.:

Synonyms:1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea

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Chemical Property of 1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea

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Technology Process of 1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea

There total 3 articles about 1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 132981-19-2
4-Trifluoromethoxy-benzoyl isocyanate

: 41774-03-2,43081-63-6
(6R)-3'-aminotetramisole

: 132981-02-3
1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea

Guidance literature:: In acetonitrile; at 70 ℃;
DOI:10.1021/jm00109a015

Reference yield:

: 36823-88-8
4-(trifluoromethoxy)benzoyl chloride

: 132981-02-3
1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea

Guidance literature:: Multi-step reaction with 3 steps

1: conc. NH₄OH / ethyl acetate / 0.17 h

2: CH₂Cl₂ / Heating

3: 92 percent / acetonitrile / 70 °C

With ammonium hydroxide; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm00109a015

Reference yield:

: 456-71-3
4-trifluoromethoxybenzamide

: 132981-02-3
1-[(S)-3-(2,3,5,6-Tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-3-(4-trifluoromethoxy-benzoyl)-urea

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂ / Heating

2: 92 percent / acetonitrile / 70 °C

In dichloromethane; acetonitrile;
DOI:10.1021/jm00109a015