(2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide

Base Information

Chemical Name:(2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide
CAS No.:498574-39-3
Molecular Formula:C₂₇H₂₉F₂N₃O₄S
Molecular Weight:529.608
Hs Code.:

Synonyms:(2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide

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Chemical Property of (2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide

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Technology Process of (2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide

There total 1 articles about (2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132741-31-2
S-(+)-3.5-Difluoromandelic Acid

: (2S)-2-amino-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)propionamide hydrochloride

: 498574-39-3
(2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2R)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide

: (2S)-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)-2-{[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino}propanamide

Guidance literature:: S-(+)-3.5-Difluoromandelic Acid; With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.333333h;

(2S)-2-amino-N-(5-{2-[(cyclohexyloxy)methyl]phenyl}-1,3-thiazol-2-yl)propionamide hydrochloride; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 18h;

With sodium hydroxide; In DMF (N,N-dimethyl-formamide); water;