N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide

Base Information

Chemical Name:N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide
CAS No.:1491137-42-8
Molecular Formula:C₂₃H₂₁N₇O
Molecular Weight:411.466
Hs Code.:

Synonyms:N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide

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Chemical Property of N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide

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Technology Process of N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide

There total 6 articles about N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181950-55-0
4-chloroquinoline-7-carbonitrile

: C₁₃H₁₇N₅O*ClH

: 1491137-42-8
N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide

Guidance literature:: C₁₃H₁₇N₅O*ClH; With triethylamine; In ethanol; at 0 ℃; Inert atmosphere;

4-chloroquinoline-7-carbonitrile; In ethanol; at 130 - 135 ℃; for 8h; Inert atmosphere; Sealed tube;
DOI:10.1016/j.ejmech.2013.08.046

Reference yield:

: 73685-56-0
N-benzyl-N-methyl-α-chloroacetamide

: 1491137-42-8
N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 °C

2.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 60 - 80 °C

3.1: trifluoroacetic acid / dichloromethane; methanol / 0 - 20 °C

4.1: hydrogenchloride / methanol; 1,4-dioxane / 0 °C

5.1: triethylamine / ethanol / 0 °C / Inert atmosphere

5.2: 8 h / 130 - 135 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.08.046

Reference yield:

: 1013663-31-4
2-azido-N-benzyl-N-methylacetamide

: 1491137-42-8
N-benzyl-2-(4-{[(7-cyanoquinolin-4-yl)amino]methyl}-1H-1,2,3-triazol-1-yl)-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 60 - 80 °C

2.1: trifluoroacetic acid / dichloromethane; methanol / 0 - 20 °C

3.1: hydrogenchloride / methanol; 1,4-dioxane / 0 °C

4.1: triethylamine / ethanol / 0 °C / Inert atmosphere

4.2: 8 h / 130 - 135 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2013.08.046