1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Base Information

Chemical Name:1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt
CAS No.:1420368-88-2
Molecular Formula:C₂HF₃O₂*C₂₃H₂₂F₃N₃O₂
Molecular Weight:543.466
Hs Code.:

Synonyms:1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

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Chemical Property of 1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

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Technology Process of 1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

There total 3 articles about 1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.3%

: 1420364-73-3
8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)ethynyl)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

: 76-05-1
trifluoroacetic acid

: 1420368-88-2
1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Guidance literature:: 8-((4-(4-chloro-3-(trifluoromethyl)phenoxy)phenyl)ethynyl)-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one; With palladium on activated charcoal; hydrogen; In methanol; for 1h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 516481-95-1
4-{[4-chloro-3-(trifluoromethyl)phenyl]oxy}benzaldehyde

: 1420368-88-2
1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol / 1 h / 20 °C

2.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

2.2: 2 h / 50 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 1 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol;

Reference yield:

: 1420364-65-3
1-chloro-4-(4-ethynylphenoxy)-2-(trifluoromethyl)benzene

: 1420362-24-8
8-chloro-1-methyl-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one

: 1420368-88-2
1-methyl-8-(4-(3-(trifluoromethyl)phenoxy)phenethyl)-3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 2 h / 50 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / methanol / 1 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium on activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; methanol;