(R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester

Base Information

• Chemical Name: (R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester
• CAS No.: 200397-98-4
• Molecular Formula: C₁₉H₂₇NO₂
• Molecular Weight: 301.429
• Mol file: 200397-98-4.mol

Synonyms:(R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester

Chemical Property of (R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester

There total 1 articles about (R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

allyl bromide (106-95-6) + [(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-acetic acid ethyl ester (107784-09-8) → (R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester (200397-98-4)

Guidance literature:

With lithium diisopropyl amide; at -70 ℃;

DOI:10.1016/S0040-4039(97)10300-8

Reference yield: 90.0%

(R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester (200397-98-4) → (R)-4-Oxo-2-[(R)-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-yl]-butyric acid ethyl ester

Guidance literature:

(R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester; With hydrogenchloride; ozone; In ethanol;

With dimethylsulfide;

With hydrogenchloride; water;

DOI:10.1016/S0040-4039(01)00977-7

Reference yield: 68.0%

(R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-pent-4-enoic acid ethyl ester (200397-98-4) → 2-<1-(1(S)-phenylethyl)pyrrolidin-2-yl>pentanoic acid ethyl ester

Guidance literature:

With hydrogen; platinum(IV) oxide;

DOI:10.1016/S0040-4039(97)10300-8

upstream raw materials:

allyl bromide

[(R)-1-((S)-1-Phenyl-ethyl)-pyrrolidin-2-yl]-acetic acid ethyl ester

Downstream raw materials:

(+)-isoretronecanol