8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

Base Information

Chemical Name:8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one
CAS No.:1255790-51-2
Molecular Formula:C₃₉H₄₃NO₇
Molecular Weight:637.773
Hs Code.:

8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

Synonyms:8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

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Chemical Property of 8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

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Technology Process of 8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

There total 9 articles about 8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1255790-53-4
C₄₈H₆₃NO₇Si

: 1255790-51-2
8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1021/ja107926f

Reference yield: 38.0%

: C₅₄H₇₈N₂O₈Si

: 1255790-51-2
8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

: 1255790-53-4
C₄₈H₆₃NO₇Si

Guidance literature:: With lithium tetrafluoroborate; In acetonitrile; at 82 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/ja107926f

Reference yield:

: 1255790-48-7
(E)-1''-(5'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-9',10'-dimethoxy-1'-methoxymethoxy-3'-methyl-8'-(triisopropylsilyloxy)anthracen-2'-yl)-4''-methylhex-4''-en-2''-yn-1''-one

: 1255790-51-2
8'-((2R,4R,5S,6R)-5-benzyloxy-4-dimethylamino-6-methyltetrahydro-2H-pyran-2-yl)-1'-((E)-but-2''-en-2''-yl)-11'-hydroxy-7',12'-dimethoxy-5'-methyl-4H-naphtho[2,3-h]chromen-4'-one

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 3 h / 20 °C / Inert atmosphere

2: lithium tetrafluoroborate; water / acetonitrile / 0.25 h / 82 °C / Inert atmosphere; Microwave irradiation

With lithium tetrafluoroborate; water; In ethanol; acetonitrile;
DOI:10.1016/j.tet.2011.05.117