(2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

Base Information

Chemical Name:(2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide
CAS No.:769950-31-4
Molecular Formula:C₃₂H₄₄ClNO₆S
Molecular Weight:606.223
Hs Code.:

(2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

Synonyms:(2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

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Chemical Property of (2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

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Technology Process of (2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

There total 4 articles about (2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.1%

: 106-47-8
4-chloro-aniline

: (20E)-3-O-(methylsulfonyl)-22-secoebelin-22-al lactone

: 769950-31-4
(2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

Guidance literature:: (20E)-3-O-(methylsulfonyl)-22-secoebelin-22-al lactone; With N-Bromosuccinimide; In tetrachloromethane; for 0.0833333h; Irradiation;

4-chloro-aniline; With triethylamine; In tetrachloromethane; at 20 ℃; for 1h;
DOI:10.1002/hlca.200490163

Reference yield:

: 54815-36-0
jujubogenin

: 769950-31-4
(2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: HCl / ethanol; H₂O / 5 h / 80 °C

2.1: pyridine / 10 h / 0 °C

3.1: O₃ / CH₂Cl₂; methanol / 1 h / -78 °C

3.2: Me₂S / CH₂Cl₂; methanol / 2 h / -10 - 0 °C

4.1: NBS / CCl₄ / 0.08 h / Irradiation

4.2: 45.1 percent / Et₃N / CCl₄ / 1 h / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; ozone; In methanol; tetrachloromethane; ethanol; dichloromethane; water;
DOI:10.1002/hlca.200490163

Reference yield:

: (1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-2'-[(1EZ,3E)-2,6-dimethylhepta-1,3,5-trienyl]dodecahydro-7'-hydroxy-4'b,8',8',10'a-tetramethylspiro[furan-3(2H),1'(2'H)-phenanthren]-5(4H)-one

: 769950-31-4
(2E)-N-(4-chlorophenyl)-2-methyl-3-[(1'S,2'R,4'aR,4'bR,7'S,8'aR,10'aR)-tetradecahydro-4'b,8',8',10'a-tetramethyl-7'-[(methylsulfonyl)oxy]-5-oxospiro[furan-3(2H),1'(2'H)-phenanthren]-2'-yl]prop-2-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 10 h / 0 °C

2.1: O₃ / CH₂Cl₂; methanol / 1 h / -78 °C

2.2: Me₂S / CH₂Cl₂; methanol / 2 h / -10 - 0 °C

3.1: NBS / CCl₄ / 0.08 h / Irradiation

3.2: 45.1 percent / Et₃N / CCl₄ / 1 h / 20 °C

With pyridine; N-Bromosuccinimide; ozone; In methanol; tetrachloromethane; dichloromethane;
DOI:10.1002/hlca.200490163