1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

Base Information

Chemical Name:1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one
CAS No.:131586-57-7
Molecular Formula:C₂₉H₃₉N₃O₃
Molecular Weight:477.647
Hs Code.:

Synonyms:1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

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Chemical Property of 1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

Chemical Property:

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Technology Process of 1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

There total 9 articles about 1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1664-61-5
dihydrocinnamamide

: 131586-57-7
1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: H₂, acetic acid / PtO₂ / ethanol

2: 5percent aq. HCl

3: H₂ / Pd/C

4: triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

5: 97 percent / K₂CO₃ / methanol / Ambient temperature

6: 1,8-diazabicyclo<5.4.0>undec-7-ene / propan-2-ol / 8 h / Heating

7: hydrazine hydrate / ethanol / 2.5 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; hydrazine hydrate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; platinum(IV) oxide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00066a010

Reference yield:

: 131587-34-3
3-[2-(1-Benzyl-piperidin-4-ylamino)-phenyl]-propionamide

: 131586-57-7
1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 5percent aq. HCl

2: H₂ / Pd/C

3: triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

4: 97 percent / K₂CO₃ / methanol / Ambient temperature

5: 1,8-diazabicyclo<5.4.0>undec-7-ene / propan-2-ol / 8 h / Heating

6: hydrazine hydrate / ethanol / 2.5 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00066a010

Reference yield:

: 1-(1-Benzyl-piperidin-4-yl)-3,4-dihydro-1H-quinolin-2-one; hydrochloride

: 131586-57-7
1-{1-[4-(8-Amino-octyloxy)-benzoyl]-piperidin-4-yl}-3,4-dihydro-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C

2: triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

3: 97 percent / K₂CO₃ / methanol / Ambient temperature

4: 1,8-diazabicyclo<5.4.0>undec-7-ene / propan-2-ol / 8 h / Heating

5: hydrazine hydrate / ethanol / 2.5 h / Heating

With hydrogen; potassium carbonate; hydrazine hydrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; isopropyl alcohol;
DOI:10.1021/jm00066a010