2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid

Base Information

• Chemical Name: 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid
• CAS No.: 1235033-31-4
• Molecular Formula: C₃₁H₂₈N₄O₄S₂
• Molecular Weight: 584.72

Synonyms:2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid

Chemical Property of 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid

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Technology Process of 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid

There total 6 articles about 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(tert-butoxycarbonyl)-1,2,3 ,4-tetrahydroisoquinoline-8-carboxylic acid (878798-87-9) → 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid (1235033-31-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C

2.1: hydrogenchloride / water; dichloromethane; diethyl ether / 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 0.17 h

3.2: 0.5 h / 20 °C

4.1: ammonia / methanol

5.1: ethanol / 6 h / 50 °C / Inert atmosphere

6.1: sodium iodide / acetonitrile / 5 h / 90 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

7.2: 1 h

8.1: hydrogenchloride / water

With hydrogenchloride; dmap; ammonia; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium iodide; In methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ml500030p

Reference yield:

C21H17N5OS2 (1627542-13-5) → 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid (1235033-31-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: ammonia / methanol

2.1: ethanol / 6 h / 50 °C / Inert atmosphere

3.1: sodium iodide / acetonitrile / 5 h / 90 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

4.2: 1 h

5.1: hydrogenchloride / water

With hydrogenchloride; ammonia; sodium hydride; sodium iodide; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ml500030p

Reference yield:

N-(benzo[d]thiazol-2-yl)-2-carbamothioyl-1,2,3,4-tetrahydroisoquinoline-8-carboxamide (1235035-45-6) → 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-phenoxybutyl)thiazole-4-carboxylic acid (1235033-31-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ethanol / 6 h / 50 °C / Inert atmosphere

2.1: sodium iodide / acetonitrile / 5 h / 90 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 1 h

4.1: hydrogenchloride / water

With hydrogenchloride; sodium hydride; sodium iodide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ml500030p

upstream raw materials:

N-(benzo[d]thiazol-2-yl)-2-carbamothioyl-1,2,3,4-tetrahydroisoquinoline-8-carboxamide

C₂₁H₁₇N₅OS₂

2-amino-benzthiazole

2-(tert-butoxycarbonyl)-1,2,3 ,4-tetrahydroisoquinoline-8-carboxylic acid

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