(E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone

Base Information

• Chemical Name: (E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone
• CAS No.: 344558-15-2
• Molecular Formula: C₁₉H₁₉BrO₂
• Molecular Weight: 359.263
• Mol file: 344558-15-2.mol

Synonyms:(E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone

Chemical Property of (E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone

There total 5 articles about (E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-4-(3'-benzoylbenzyloxy)-3-methyl-2-buten-1-ol (344558-14-1) → (E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone (344558-15-2)

Guidance literature:

With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo991130x

Reference yield:

1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-butene (54105-78-1) → (E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone (344558-15-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 33 percent / t-Bu-OOH; H₂SeO₃; salicylic acid / CH₂Cl₂ / 10 h / 20 °C

2.1: NaH / tetrahydrofuran / 1 h / 0 °C

2.2: 68 percent / tetrahydrofuran / 0 - 20 °C

3.1: 100 percent / PPTs / ethanol / 8 h / 55 °C

4.1: CBr₄; PPh₃ / CH₂Cl₂ / 4 h / 20 °C

With tert.-butylhydroperoxide; carbon tetrabromide; pyridinium p-toluenesulfonate; selenious acid; sodium hydride; triphenylphosphine; salicylic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jo991130x

Reference yield:

(E)-1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-buten-4-ol (156835-27-7) → (E)-(3-((4-bromo-2-methylbut-2-enyloxy)methyl)phenyl)(phenyl)methanone (344558-15-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: NaH / tetrahydrofuran / 1 h / 0 °C

1.2: 68 percent / tetrahydrofuran / 0 - 20 °C

2.1: 100 percent / PPTs / ethanol / 8 h / 55 °C

3.1: CBr₄; PPh₃ / CH₂Cl₂ / 4 h / 20 °C

With carbon tetrabromide; pyridinium p-toluenesulfonate; sodium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jo991130x

upstream raw materials:

(E)-4-(3'-benzoylbenzyloxy)-3-methyl-2-buten-1-ol

1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-butene

(E)-1-[(tetrahydro-2H-pyran-2-yl)oxy]-3-methyl-2-buten-4-ol

3-methyl-2-buten-1-ol

Downstream raw materials:

C₇₇H₁₁₂N₁₆O₁₉S₂

YIIKGVFWDPAC(BC₅)-OCH₃