N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

Base Information

Chemical Name:N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine
CAS No.:1610359-12-0
Molecular Formula:C₁₉H₁₆ClF₂N₃OS
Molecular Weight:407.871
Hs Code.:

Synonyms:N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

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Chemical Property of N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

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Technology Process of N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

There total 6 articles about N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610359-13-1
N-[6-chloro-4-(chloromethyl)pyridin-2-yl]-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

: 5188-07-8
sodium thiomethoxide

: 1610359-12-0
N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

Guidance literature:: In water; acetone; at 20 ℃; for 6h;

Reference yield:

: 1602486-03-2
2-chloro-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridine

: 1610359-12-0
N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hexamethyldisilazane; XPhos / 1,4-dioxane / 6 h / 60 °C / Inert atmosphere

2: XPhos; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; potassium phosphate / 1-methyl-pyrrolidin-2-one; toluene / 2.25 h / 110 °C / Inert atmosphere

3: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

4: water; acetone / 6 h / 20 °C

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; thionyl chloride; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; lithium hexamethyldisilazane; XPhos; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1602486-07-6
5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

: 1610359-12-0
N-{6-chloro-4-[(methylsulfanyl)methyl]pyridin-2-yl}-5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: XPhos; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; potassium phosphate / 1-methyl-pyrrolidin-2-one; toluene / 2.25 h / 110 °C / Inert atmosphere

2: thionyl chloride / N,N-dimethyl-formamide / 2 h / 0 - 20 °C

3: water; acetone / 6 h / 20 °C

With potassium phosphate; thionyl chloride; chloro(2-dicyclohexylphosphino-2',4',6'-tri-iso-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl]palladium(II) methyl-tert-butyl ether adduct; XPhos; In 1-methyl-pyrrolidin-2-one; water; N,N-dimethyl-formamide; acetone; toluene;