(S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

Base Information

Chemical Name:(S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate
CAS No.:1261543-46-7
Molecular Formula:C₂₇H₂₈N₂O₆
Molecular Weight:476.529
Hs Code.:

Synonyms:(S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

Suppliers and Price of (S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

There total 1 articles about (S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 4039-82-1
Benzyl propargyl ether

: 1242425-61-1
C₁₇H₁₉ClN₂O₅

: 1261543-46-7
(S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

Guidance literature:: Benzyl propargyl ether; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h; Inert atmosphere;

With dimethylaluminum chloride; In tetrahydrofuran; hexane; at 0 ℃; for 1h; Inert atmosphere;

C₁₇H₁₉ClN₂O₅; In tetrahydrofuran; hexane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol102678j

Reference yield:

: 1261543-46-7
(S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

: 1261543-62-7
ethyl 5-(2-(2-(3-(2-(benzyloxycarbonylamino)ethyl)-1H-indol-4-yl)phenylamino)-2-oxoethyl)-2-((S)-1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trichloride / dichloromethane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / Reflux

2.1: Jones reagent / acetone / 4 h / 20 °C / Inert atmosphere

3.1: thionyl chloride / 3 h / 20 °C / Inert atmosphere

4.1: pyridine / tetrahydrofuran; dichloromethane / 36 h / 20 °C / Inert atmosphere

With pyridine; Jones reagent; thionyl chloride; boron trichloride; In tetrahydrofuran; dichloromethane; acetone; 2.1: Jones oxidation;
DOI:10.1021/ol102678j

Reference yield:

: 1261543-46-7
(S)-ethyl 5-(2-(benzyloxy)ethyl)-2-(1-(1,3-dioxoisoindolin-2-yl)-2-methylpropyl)oxazole-4-carboxylate

: 1261543-65-0
C₄₄H₄₁N₅O₉

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron trichloride / dichloromethane / 1 h / -78 °C / Inert atmosphere

1.2: 1 h / Reflux

2.1: Jones reagent / acetone / 4 h / 20 °C / Inert atmosphere

3.1: thionyl chloride / 3 h / 20 °C / Inert atmosphere

4.1: pyridine / tetrahydrofuran; dichloromethane / 36 h / 20 °C / Inert atmosphere

5.1: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran / 4 h / 0 °C / Inert atmosphere

With pyridine; Jones reagent; thionyl chloride; water; boron trichloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; acetone; 2.1: Jones oxidation;
DOI:10.1021/ol102678j