Technology Process of 1-chloro-4-(2,5-dimethoxyphenyl)-2-butylidenemalononitrile
There total 5 articles about 1-chloro-4-(2,5-dimethoxyphenyl)-2-butylidenemalononitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonium acetate; acetic acid;
In
benzene;
for 4h;
Heating;
DOI:10.1021/jm00073a009
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 91 percent / H2 / 10percent Pd/C / ethanol / 9 h / 25 °C
2: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, from -78 deg C to RT
3: 1.) N-chlorosuccinimide, 2.) citric acid / 1.) CH2Cl2, reflux, 1 h, 2.) MeOH, RT, 1,5 h
4: 71 percent / glacial AcOH, NH4OAc / benzene / 4 h / Heating
With
N-chloro-succinimide; ammonium acetate; hydrogen; acetic acid; citric acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
ethanol; benzene;
DOI:10.1021/jm00073a009
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / CH2Cl2 / 60 h / Heating
2: 91 percent / H2 / 10percent Pd/C / ethanol / 9 h / 25 °C
3: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, from -78 deg C to RT
4: 1.) N-chlorosuccinimide, 2.) citric acid / 1.) CH2Cl2, reflux, 1 h, 2.) MeOH, RT, 1,5 h
5: 71 percent / glacial AcOH, NH4OAc / benzene / 4 h / Heating
With
N-chloro-succinimide; ammonium acetate; hydrogen; acetic acid; citric acid; lithium diisopropyl amide;
palladium on activated charcoal;
In
ethanol; dichloromethane; benzene;
DOI:10.1021/jm00073a009
