(E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid

Base Information

Chemical Name:(E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid
CAS No.:917022-72-1
Molecular Formula:C₃₃H₄₂O₄
Molecular Weight:502.694
Hs Code.:

Synonyms:(E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid

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Chemical Property of (E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid

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Technology Process of (E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid

There total 10 articles about (E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: (E)-3-{5-[4-(1-{4-[3-(t-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenyl]-furan-2-yl}-acrylic acid ethyl ester

: 917022-72-1
(E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid

Guidance literature:: (E)-3-{5-[4-(1-{4-[3-(t-butyl-dimethyl-silanyloxy)-4,4-dimethyl-pentyl]-3-methyl-phenyl}-1-ethyl-propyl)-2-methyl-phenyl]-furan-2-yl}-acrylic acid ethyl ester; With potassium hydroxide; water; In tetrahydrofuran; methanol; at 60 ℃; for 2h;

With potassium hydrogensulfate; In water; ethyl acetate;

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 65 ℃; for 1h;

Reference yield:

: 4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pent-1-ynyl)-3-methyl-phenyl]-propyl}-2-methyl-phenol

: 917022-72-1
(E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 0.67 h

2.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C

2.2: 0.08 h / 0 °C

3.1: pyridine / dichloromethane / 0.33 h / 20 °C

4.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 15 h / 60 °C

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

6.1: potassium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

6.3: 1 h / 65 °C

With pyridine; 2,6-dimethylpyridine; potassium hydroxide; water; hydrogen; sodium hydride; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; ethyl acetate;

Reference yield:

: 865236-24-4
4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenol

: 917022-72-1
(E)-3-[5-(4-{1-ethyl-1-[4-(3-hydroxy-4,4-dimethyl-pentyl)-3-methyl-phenyl]-propyl}-2-methyl-phenyl)-furan-2-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 0.5 h / 0 °C

1.2: 0.08 h / 0 °C

2.1: pyridine / dichloromethane / 0.33 h / 20 °C

3.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 15 h / 60 °C

4.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

5.1: potassium hydroxide; water / tetrahydrofuran; methanol / 2 h / 60 °C

5.3: 1 h / 65 °C

With pyridine; 2,6-dimethylpyridine; potassium hydroxide; water; sodium hydride; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;