(S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide

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Chemical Name:(S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide
CAS No.:494859-00-6
Molecular Formula:C₂₈H₃₈N₄O₄
Molecular Weight:494.634
Hs Code.:

Synonyms:(S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide

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Chemical Property of (S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide

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Technology Process of (S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide

There total 7 articles about (S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 494859-00-6
(S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ClCO₂iBu; Et₃N

1.2: Et₃N

2.1: LiOH / methanol; H₂O

3.1: ClCO₂iBu; Et₃N

3.2: Et₃N

With lithium hydroxide; triethylamine; isobutyl chloroformate; In methanol; water;
DOI:10.1016/S0040-4039(02)01601-5

Reference yield:

: 84024-60-2,84024-61-3
trans-3-phenylaziridine-2-carboxylic acid ethyl ester

: 494859-00-6
(S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 41 percent / ClCO₂iBu; Et₃N / 0 °C

2.1: 46 percent / Me₃SiI; Et₃N / acetonitrile

3.1: LiOH / methanol; H₂O

4.1: ClCO₂iBu; Et₃N

4.2: Et₃N

5.1: LiOH / methanol; H₂O

6.1: ClCO₂iBu; Et₃N

6.2: Et₃N

With lithium hydroxide; trimethylsilyl iodide; triethylamine; isobutyl chloroformate; In methanol; water; acetonitrile;
DOI:10.1016/S0040-4039(02)01601-5

Reference yield:

: N-4-pentenoyl-(S)-proline

: 494859-00-6
(S)-1-Pent-4-enoyl-pyrrolidine-2-carboxylic acid [(Z)-1-((S)-1-allylcarbamoyl-3-methyl-butylcarbamoyl)-2-phenyl-vinyl]-amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 41 percent / ClCO₂iBu; Et₃N / 0 °C

2.1: 46 percent / Me₃SiI; Et₃N / acetonitrile

3.1: LiOH / methanol; H₂O

4.1: ClCO₂iBu; Et₃N

4.2: Et₃N

5.1: LiOH / methanol; H₂O

6.1: ClCO₂iBu; Et₃N

6.2: Et₃N

With lithium hydroxide; trimethylsilyl iodide; triethylamine; isobutyl chloroformate; In methanol; water; acetonitrile;
DOI:10.1016/S0040-4039(02)01601-5