N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Base Information

Chemical Name:N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide
CAS No.:1429202-35-6
Molecular Formula:C₂₃H₁₉ClF₄N₂O₄
Molecular Weight:498.861
Hs Code.:

Synonyms:N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

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Chemical Property of N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

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Technology Process of N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

There total 5 articles about N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

: 1429204-54-5
N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

: 1429202-35-6
N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Guidance literature:: With boron tribromide; In dichloromethane; at 3 ℃; for 20h;

Reference yield:

: 130879-43-5
3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester

: 1429202-35-6
N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C

2: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 0.5 h / 160 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: lithium hydroxide / water; tetrahydrofuran; methanol / 65 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 48 h / 20 °C

5: boron tribromide / dichloromethane / 20 h / 3 °C

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron tribromide; sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1429204-53-4
6-(3-fluoro-5-(trifluoromethyl)phenyl)-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

: 1429202-35-6
N-(3-(2-chlorophenoxy)propyl)-6-(3-fluoro-5-(trifluoromethyl)phenyl)3-hydroxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 48 h / 20 °C

2: boron tribromide / dichloromethane / 20 h / 3 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron tribromide; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;