4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid

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Chemical Name:4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid
CAS No.:1379647-36-5
Molecular Formula:CH₂O₂*C₂₆H₃₂FN₃O₃
Molecular Weight:499.582
Hs Code.:

Synonyms:4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid

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Chemical Property of 4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid

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Technology Process of 4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid

There total 5 articles about 4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5625-67-2
2-Ketopiperazine

: 1379647-54-7
2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]amino]-cyclopentyl]phenyl]acetic acid

: 1379647-36-5
4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid

Guidance literature:: 2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]amino]-cyclopentyl]phenyl]acetic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

2-Ketopiperazine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 930-30-3
cyclopent-2-enone

: 1379647-36-5
4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / [Rh((R)-BINAP)(norbornadiene)]BF₄ / methanol / 0.33 h / 100 °C / Sealed vial; Microwave reactor

2.1: NaBH(OAc)3 / acetonitrile / 2 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

3.2: pH ~ 5

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 20 °C

With NaBH(OAc)3; water; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; [Rh((R)-BINAP)(norbornadiene)]BF₄; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 859169-20-3
1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester

: 1379647-36-5
4-[2-[4-[(1R,3S)-3-[[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-amino]-cyclopentyl]phenyl]acetyl]piperazin-2-one formic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / [Rh((R)-BINAP)(norbornadiene)]BF₄ / methanol / 0.33 h / 100 °C / Sealed vial; Microwave reactor

2.1: NaBH(OAc)3 / acetonitrile / 2 h / 20 °C

3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 20 °C

3.2: pH ~ 5

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 20 °C

With NaBH(OAc)3; water; triethylamine; 1,1'-carbonyldiimidazole; sodium hydroxide; [Rh((R)-BINAP)(norbornadiene)]BF₄; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;