N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide

Base Information

Chemical Name:N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide
CAS No.:131758-54-8
Molecular Formula:C₂₂H₃₁N₃O₂S
Molecular Weight:401.573
Hs Code.:

Synonyms:N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide

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Technology Process of N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide

There total 2 articles about N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 6001-74-7
2-(4-methylthiazol-5-yl)ethyl chloride hydrochloride

: 61086-18-8
N-[4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide

: 131758-54-8
N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide

Guidance literature:: With sodium carbonate; sodium iodide; In acetonitrile; Heating;
DOI:10.1021/jm00106a051

Reference yield:

: 137-00-8,8042-97-5
5-hydroxyethyl-4-methylthiazole

: 131758-54-8
N-{4-Methoxymethyl-1-[2-(4-methyl-thiazol-5-yl)-ethyl]-piperidin-4-yl}-N-phenyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 71 percent / SOCl₂ / benzene / 15 h

2: 63 percent / Na₂CO₃, NaI / acetonitrile / Heating

With thionyl chloride; sodium carbonate; sodium iodide; In acetonitrile; benzene;
DOI:10.1021/jm00106a051