2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione

Base Information

• Chemical Name: 2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione
• CAS No.: 124887-39-4
• Molecular Formula: C₃₆H₂₈O₅
• Molecular Weight: 540.615
• Mol file: 124887-39-4.mol

Synonyms:2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione

Chemical Property of 2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione

There total 12 articles about 2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C36H30O5 (124887-38-3) → 2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione (124887-39-4)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 14h; Yield given; Ambient temperature;

DOI:10.1021/jo00293a043

Reference yield:

3-(1-Hydroxymethyl)-2-<1-hydroxy-1-<7'-(phenylmethoxy)-1'-indanyl>methyl>-4-methoxy-1-(phenylmethoxy)-naphthalene (124887-36-1) → 2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione (124887-39-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 66 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂ / 1 h / -67 °C

2: NaOCH₃ / methanol / 3 h / 60 °C

3: PCC / CH₂Cl₂ / 14 h / 25 °C

With oxalyl dichloride; sodium methylate; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; In methanol; dichloromethane;

DOI:10.1016/S0040-4039(01)93705-0

Reference yield:

2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol (124887-34-9) → 2,3-dihydro-7-(phenylmethoxy)-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione (124887-39-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / K₂CO₃, (Bu)4NI / dimethylformamide / 48 h / 25 °C

2: 68 percent / (Bu)4NF / tetrahydrofuran / 72 h / 25 °C

3: 66 percent / (COCl)2, DMSO, Et₃N / CH₂Cl₂ / 1 h / -67 °C

4: NaOCH₃ / methanol / 3 h / 60 °C

5: PCC / CH₂Cl₂ / 14 h / 25 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium methylate; tetra-(n-butyl)ammonium iodide; potassium carbonate; dimethyl sulfoxide; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)93705-0

upstream raw materials:

C₃₆H₃₀O₅

2-<1-oxo-1-<7'-(phenylmethoxy)-1'-indanyl>methyl>-4-methoxy-1-(phenylmethoxy)naphthalene-3-carboxaldehyde

3-(1-Hydroxymethyl)-2-<1-hydroxy-1-<7'-(phenylmethoxy)-1'-indanyl>methyl>-4-methoxy-1-(phenylmethoxy)-naphthalene

2-<1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-1-methoxy-3-<1-<(7'-phenylmethoxy)-1'-indanyl>-1-<<(1,1-dimethylethyl)dimethylsilyl>oxy>methyl>-4-naphthalenol

Downstream raw materials:

2,3-dihydro-7-hydroxy-1H-indene-1-spiro-2'-<4'-methoxy-9'-(phenylmethoxy)-2'H-benzindene>-1',3'-dione