(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine

Base Information

Chemical Name:(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine
CAS No.:479253-11-7
Molecular Formula:C₃₁H₂₈NO₃P
Molecular Weight:493.542
Hs Code.:

Synonyms:(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine

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Chemical Property of (1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine

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Technology Process of (1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine

There total 1 articles about (1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 552-79-4
(-)-N-methylephedrine

: 137156-22-0,171878-71-0,155613-52-8
binaphthol chlorophosphite

: 479253-11-7
(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine

Guidance literature:: With triethylamine; In toluene;
DOI:10.1016/S0022-328X(02)01561-9

Reference yield: 90.0%

: di(rhodium)tetracarbonyl dichloride

: 479253-11-7
(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine

: chloro[(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine]monocarbonylrhodium(I)

Guidance literature:: In dichloromethane; byproducts: CO; under Ar; soln. of ligand in CH2Cl2 added dropwise to stirred soln. of Rh complex (molar ratio 2:1) in CH2Cl2 at 20°C; stirred at 20°C for 0.5 h; excess of solvent removed in vac.; C6H14 added; ppt. sepd. by centrifugation; washed with C6H14; dried in vac.; elem. anal.;
DOI:10.1016/S0022-328X(02)01561-9

Reference yield:

: 12107-56-1
dichloro(cycloocta-1,5-diene)palladium (II)

: 479253-11-7
(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine

: dichlorobis[η1-P-(1'R,2'S)-2-(2'-dimethylamino-1'-phenyl-propoxy)dinaphtho[2,1-d:1',2'-f](1,3,2) dioxaphosphepine]palladium(II)

Guidance literature:: In chloroform-d1; byproducts: COD; under Ar; in NMR tube; soln. of ligand in CDCl3 added dropwise to stirred soln. of Pd complex (molar ratio 2:1) in CDCl3; not isolated; detd. by (31)P NMR spectra;
DOI:10.1016/S0022-328X(02)01561-9